Clues to restoring normal function in gene that causes cystic fibrosis

A recent study publish in Cell has shown that to restore normal function to the mutant gene product that causes Cystic Fibrosis (CF), it is necessary to correct two structural defects. CF is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), the most common mutation being deltaF508, which results in a misfolded version of CFTR. The research team went off the evidence that the effects of the mutation were not limited to the domain of deltaF508, but...