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A drug approved for human clinical trials extends lifespan in mice with muscle wasting disease

Scientists have found a way to extend the average lifespan of mice with spinal muscular atrophy (SMA), the leading inherited cause of death in human infants and toddlers. SMA is caused by genetic mutations in survival motor neuron 1 (SMN1). Two years ago, the same research team found that a compound called Y-27632 could increase the lifespan of a certain mouse model by targeting an enzyme that maintains the cellular scaffold. Now, the scientists have shown that another compound, fasudil...

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